Yusuf A Hannun Selected Research

sphingosine kinase

1/2022	1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase.
1/2021	Sphingosine kinase 1 downregulation is required for adaptation to serine deprivation.
1/2021	Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer.
1/2018	A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway.
1/2018	An intrinsic lipid-binding interface controls sphingosine kinase 1 function.
12/2017	Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis.
1/2017	Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.
11/2015	Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.
7/2015	A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.
1/2014	Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease.

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Yusuf A Hannun Research Topics

Disease

79	Neoplasms (Cancer) 01/2022 - 01/2004
22	Inflammation (Inflammations) 01/2021 - 04/2007
17	Breast Neoplasms (Breast Cancer) 07/2021 - 10/2002
10	Squamous Cell Carcinoma of Head and Neck 01/2019 - 10/2004
9	Mitochondrial Diseases (Mitochondrial Disease) 10/2021 - 10/2002
8	Colonic Neoplasms (Colon Cancer) 01/2021 - 02/2006
7	Carcinogenesis 12/2017 - 02/2006
6	Neoplasm Metastasis (Metastasis) 07/2021 - 10/2007
6	Leukemia 01/2021 - 01/2004
5	Lung Neoplasms (Lung Cancer) 05/2021 - 03/2009
5	Carcinoma (Carcinomatosis) 01/2021 - 08/2004
5	Adenocarcinoma of Lung 11/2019 - 04/2002
5	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2018 - 01/2009
5	Insulin Resistance 01/2018 - 05/2008
5	Obesity 01/2018 - 09/2006
5	Colitis 01/2017 - 01/2009
5	Prostatic Neoplasms (Prostate Cancer) 11/2012 - 09/2007
5	Necrosis 04/2011 - 03/2005
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 05/2011
4	Gaucher Disease (Gaucher's Disease) 01/2015 - 02/2010
3	Starvation 01/2022 - 02/2010
3	Niemann-Pick Diseases (Niemann Pick Disease) 01/2015 - 06/2009
2	Acute Kidney Injury (Acute Renal Failure) 01/2022 - 01/2017
2	COVID-19 10/2021 - 02/2021
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 05/2021 - 11/2019
2	Melanoma (Melanoma, Malignant) 01/2021 - 04/2002
2	Fibrosis (Cirrhosis) 01/2020 - 03/2003
2	Farber Lipogranulomatosis 12/2018 - 08/2014
2	Colorectal Neoplasms (Colorectal Cancer) 11/2018 - 01/2018
2	Cerebellar Ataxia (Dysmetria) 01/2018 - 10/2015
2	Splenomegaly 01/2017 - 01/2009
2	Reperfusion Injury 03/2016 - 01/2010
2	Metabolic Diseases (Metabolic Disease) 02/2014 - 09/2006

Drug/Important Bio-Agent (IBA)

67	CeramidesIBA 01/2021 - 04/2002
47	SphingolipidsIBA 01/2021 - 08/2004
29	EnzymesIBA 05/2021 - 01/2006
19	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2021 - 01/2008
17	sphingosine kinaseIBA 01/2022 - 02/2006
16	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 01/2021 - 06/2004
15	Acid CeramidaseIBA 11/2020 - 08/2006
10	SphingosineIBA 01/2022 - 01/2006
9	Neutral CeramidaseIBA 01/2022 - 12/2012
8	LipidsIBA 01/2022 - 02/2008
8	Proteins (Proteins, Gene)FDA Link 01/2019 - 04/2002
7	AcidsIBA 06/2015 - 06/2009
7	SphingomyelinsIBA 08/2014 - 10/2002
6	CytokinesIBA 11/2020 - 11/2010
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2009 - 03/2005
5	Messenger RNA (mRNA)IBA 01/2021 - 04/2002
5	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2021 - 02/2007
5	Alkaline CeramidaseIBA 01/2018 - 10/2015
5	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 12/2017 - 02/2006
4	Biological ProductsIBA 01/2022 - 04/2002
4	Fatty Acids (Saturated Fatty Acids)IBA 07/2021 - 01/2010
4	CeramidasesIBA 01/2021 - 04/2002
4	Biomarkers (Surrogate Marker)IBA 01/2021 - 09/2011
4	AzoxymethaneIBA 12/2017 - 02/2006
4	Glucosylceramides (Glucocerebrosides)IBA 01/2017 - 02/2010
4	Small Interfering RNA (siRNA)IBA 01/2011 - 08/2004
4	Cytochromes c (Cytochrome c)IBA 09/2008 - 10/2002
4	Caspase 9IBA 02/2007 - 04/2002
3	Serine (L-Serine)FDA Link 01/2022 - 11/2018
3	Cisplatin (Platino)FDA LinkGeneric 01/2022 - 04/2008
3	NitrogenIBA 10/2021 - 02/2010
3	IsoenzymesIBA 05/2021 - 01/2009
3	Protein Kinase CIBA 05/2021 - 12/2006
3	dihydroceramide desaturaseIBA 01/2021 - 06/2007
3	Phosphotransferases (Kinase)IBA 01/2021 - 10/2008
3	Nonesterified Fatty Acids (NEFA)IBA 01/2018 - 10/2013
3	CateninsIBA 01/2018 - 05/2014
3	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2016 - 01/2006
3	p38 Mitogen-Activated Protein KinasesIBA 01/2015 - 10/2008
3	Interleukin-6 (Interleukin 6)IBA 01/2015 - 08/2014
3	Dextran SulfateIBA 01/2014 - 01/2009
3	FenretinideIBA 04/2012 - 07/2011
3	Gemcitabine FDA Link 09/2011 - 06/2006
3	SaposinsIBA 04/2011 - 02/2010
3	Caspase 3 (Caspase-3)IBA 03/2011 - 06/2006
2	Alanine (L-Alanine)FDA Link 01/2022 - 11/2018
2	Secretory Phospholipases A2IBA 10/2021 - 02/2021
2	Urea (Carbamide)FDA LinkGeneric 10/2021 - 02/2021
2	PalmitatesIBA 07/2021 - 01/2018
2	Protein Isoforms (Isoforms)IBA 05/2021 - 04/2011
2	Phospholipases (Phospholipase)IBA 02/2021 - 01/2010
2	Mechanistic Target of Rapamycin Complex 1IBA 11/2019 - 01/2014
2	GTP Phosphohydrolases (GTPases)IBA 01/2019 - 09/2012
2	CarcinogensIBA 01/2018 - 04/2015
2	Dinoprostone (PGE2)FDA Link 12/2017 - 02/2006
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 11/2015 - 03/2003
2	LipopolysaccharidesIBA 05/2015 - 10/2013
2	GlucosidasesIBA 01/2015 - 04/2011
2	LipofuscinIBA 01/2015 - 05/2011
2	Insulin (Novolin)FDA Link 04/2014 - 01/2014
2	Glucose (Dextrose)FDA LinkGeneric 04/2014 - 01/2014
2	Phosphatidylcholines (Phosphatidylcholine)IBA 11/2012 - 10/2008
2	dihydroceramideIBA 04/2012 - 11/2011
2	RetinoidsIBA 04/2012 - 11/2011

Therapy/Procedure

25	Therapeutics 05/2021 - 09/2005
7	Drug Therapy (Chemotherapy) 05/2021 - 01/2005
3	Chemoprevention 02/2013 - 02/2009